The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women

Abstract Objective To assess the prevalence and distribution of HPV genotypes among Chinese Han women, to explore risk high-grade cervical lesions associated with individual hr-HPV genotypes. Methods Genotyping histopathology data from Multi-Center Screening Trial (CHIMUST) its pilot screening trial, 6 regions across mainland China, were re-analyzed. The physician- self-collected samples 10,867 women (ages 30–69) used determine association between precancerous lesions. Results 9.2% study population tested positive in physician-collected sample. varied regionally lowest Guangdong (6.3%) highest Inner Mongolia (13.0%). most prevalent found HPV-52 (21.7%), HPV-16 (19.2%), HPV-58 (15.0%), HPV-39 (8.9%), HPV-51 (8.2%). overall odds ratios for CIN2+ CIN3+ presence was 58.6 (95% CI 39.2–87.5) and, 91.6 (95%CI 54.3–154.6), respectively remained ratio all regions. Conclusion Geographical variation exists China. HPV-16/52/58 genotypes, had registration CHIMUST, Registration number: ChiCTR-EOC-16008456 . Registered 11 May 2016.